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Is there _______ wrong with you today?
A.nothingB.somethingC.anythingD.everything
C

此题考查的是不定代词+形容词。anything一般用于否定句和疑问句,something用于肯定句以及希望得到对方肯定回答的疑问句中,如Would you like something to drink? 本题只是一般的疑问句,故选C。nothing表示什么也没有,everything表示一切东西。
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