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What’s wrong ____ you?

A. about B. with C. of D. on

B 【解析】 句意:你怎么了?A. about关于;B. with与……一起;C. of……的;D. on在……上。本题考查固定句子结构What’s wrong with ...?“……怎么了/出什么事了?” 故答案为B。
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