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. John hadn’t been able to quit smoking at once; he had to control his smoking desire      .
A.more or lessB.by and byC.little by littleD.now and then
C

词组辨析;A. more or less或多或少B. by and by逐渐的C. little by little一点一点的D. now and then时而,句意是:约翰不能立刻戒烟,他不得不一点一点的控制抽烟的欲望。所以选C。
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