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    He was determined to hold on to this job ___ difficulties he might run into.

    A．whatever B．however C．no matter how D．no matter

    A

    解析试题分析： 句意：他决定无论他会遇到什么困难，他都决定坚持工作。这里用whatever引导让步状语从句，相当于no matter what修饰difficulty，no matter how/however是修饰形容词或副词，所以选A。
    考点：考查让步状语从句

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