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Usually what weighs us down are not the burdens of life, but how we handle _______ .
A.thisB.themC.itD.us
B
考察代词。This 代指后文提到的事物 them代指上文提到的复数名词  it代指上文提到的单数名词 us代指人,我们。 此处them代指的是前一句中的burdens,故选择B
句意为,通常让我们感到疲惫的不是生活的压力,而是处理这些压力的方式。
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