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    A serious illness, ______ its nature, is almost always painful.

    A．whatever B．wherever C．whenever D．however

    A

    解析试题分析：考察让步状语从句，本句在nature后面省略了is。Whatever引导起这个让步状语从句，并在句中作为is 的表语。BCD三项都是副词，通常不能在句中作表语。句意：无论是什么样的性质，一种严重的疾病总是会让人痛苦。故A正确。
    考点：考察让步状语从句

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