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A serious study of physics is impossible     some knowledge of mathematics.
A.againstB.beforeC.beyondD.without
D
考查介词辨析。against反对,衬托;before在......之前;beyond超过;without没有。句意“没有一些数学知识的话,一个严肃的物理研究是不可能的。”故选D。
【考点定位】介词辨析。
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