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No one knows how large          universe is, but          man has never given up the  attempt to explore new stars and new planets.
A. the;/           B/; the               C/:/             D the; the
A
考查冠词的用法。a/an表示泛指,“一个”;the表示特指,“那个”。universe“宇宙”,不可数名词,且是独一无二的事物,一个用the修饰;man“人类”,前不加冠词。故选A。
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