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He tried his best to solve the problem, _______ difficult it was.

A.whatever B.however C.whichever D.wherever 

B

解析试题分析:No matter +特殊疑问词引导让步状语从句,意为:无论…;意为后面接形容词difficult,所以使用how.而不是what. 句意:无论问题有多难,他都全力以赴地解决它。故B正确。
考点:考查让步状语从句

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