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If we work with a strong will, we can overcome any difficulty, _____great it is.

A.whatB.howC.howeverD.whatever

C

解析试题分析:考查疑问词引导从句的区别。句意:如果我们有坚强的意志工作,我们就可以克服任何困难,无论它有多大。However引导让步壮语从句时等于“no matter how”,且这个词引导让步状语从句时,从句后面如果有形容词或副词,一定要把形容词或副词放到从句主语和however之间。故C正确。
考点:疑问词引导从句的区别。

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