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—Your sister’s plan is not quite practical.Why not try to persuade her to give it up?
—My sister is very stubborn,so it is________to try to change her mind.
A.by chanceB.in vain
C.on purposeD.for sure
B

句意为:——你妹妹的计划不是很切合实际。为何不劝她放弃?——我妹妹很固执,所以要她改变主意根本就是白费力气。in vain意为“枉费心机,白费力气”。by chance碰巧,凑巧;on purpose故意地;for sure毫无疑问。
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