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—How amazing it is that astronauts are exploring outer space!
—It's a challenge, I guess, ______  man against nature.
A.of B.for
C.by D.about
A
A 考察介词。应答句中的I guess是插入语,因此所填介词与challenge连用,表所属,使用of。选A。句义:我猜想它是人对自然的挑战。
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