解:(1)333×666+999×778,
=333×(3×222)+999×778,
=999×222+999×778,
=999×(222+778),
=999×1000,
=999000;
(2)

×7

+0.25×5

÷

,
=

×7

+

×5

×4,
=

×(7

+

×4),
=

×(7

+22

),
=

×

,
=

;
(3)8.69-1

÷(0.375×

+

×0.8),
=8.69-1

÷(

×

+0.1),
=8.69-1

÷(

×

+

),
=8.69-1

÷(

+

),
=8.69-

÷

,
=8.69-

×

,
=8.69-4,
=4.69;
(4)538×

×3

-2

×0.538×125,
=538×

×

-2

×538×0.125,
=538×(

-

×0.125),
=538×(1.35-0.35),
=538×1,
=538.
分析:(1)把666看作333×2,原式变为333×(3×222)+999×778,即999×222+999×778,运用乘法分配律简算.
(2)把除法改为乘法,运用乘法分配律简算.
(3)先算括号内的乘法,再算括号内的加法,然后算括号外的热除法,最后算减法.
(4)根据数字特点,原式变为538×

×

-2

×538×0.125,运用乘法分配律简算.
点评:完成本题要注意分析式中数据,运用合适的简便方法计算.